I am having with trouble opening a lot of applications on my pc. I can't even open windows media player.
[B]
LOG FILE FROM HIJACK THIS[/B]

Logfile of HijackThis v1.98.0
Scan saved at 10:06:49 PM, on 7/2/2004
Platform: Windows XP (WinNT 5.01.2600)
MSIE: Internet Explorer v6.00 (6.00.2600.0000)

Running processes:
C:\WINDOWS\System32\smss.exe
C:\WINDOWS\system32\winlogon.exe
C:\WINDOWS\system32\services.exe
C:\WINDOWS\system32\lsass.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\System32\svchost.exe
C:\WINDOWS\system32\spoolsv.exe
C:\WINDOWS\Nhksrv.exe
C:\PROGRA~1\SYMANT~1\SYMANT~1\DefWatch.exe
C:\PROGRA~1\SYMANT~1\SYMANT~1\Rtvscan.exe
C:\WINDOWS\System32\nvsvc32.exe
C:\WINDOWS\Explorer.EXE
C:\Program Files\Common Files\Microsoft Shared\Works Shared\WkUFind.exe
C:\WINDOWS\DELLMMKB.EXE
C:\Program Files\Common Files\CMEII\CMESys.exe
C:\Program Files\DelFin\PromulGate\PgMonitr.exe
C:\Program Files\DownloadWare\dw.exe
C:\WINDOWS\System32\DeltTray.exe
C:\Program Files\Adaptec\Easy CD Creator 5\DirectCD\DirectCD.exe
C:\PROGRA~1\SYMANT~1\SYMANT~1\vptray.exe
C:\Program Files\Common Files\Real\Update_OB\evntsvc.exe
C:\Program Files\desksite\bin\cma.exe
C:\Program Files\Date Manager\DateManager.exe
C:\Program Files\Netropa\OSD.exe
C:\Program Files\Common Files\GMT\GMT.exe
C:\WINDOWS\system32\NOTEPAD.EXE
C:\Program Files\Internet Explorer\iexplore.exe
Z:\Documents and Settings\ksethoko\Desktop\hijackthis.exe

R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Default_Page_URL = http://www.dellnet.com/
R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Start Page = http://dellnet.msn.com/
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Page_URL = http://www.dellnet.com/
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = http://www.dellnet.com/
O2 - BHO: AcroIEHlprObj Class - {06849E9F-C8D7-4D59-B87D-784B7D6BE0B3} - C:\Program Files\Adobe\Acrobat 5.0\Reader\ActiveX\AcroIEHelper.ocx
O2 - BHO: IEHlprObj Class - {40AC4D2D-491D-11D4-AAF2-0008C75DCD2B} - C:\WINDOWS\SYSTEM32\mbho.dll
O2 - BHO: YBIOCtrl Class - {EF99BD32-C1FB-11D2-892F-0090271D4F88} - (no file)
O3 - Toolbar: &Radio - {8E718888-423F-11D2-876E-00A0C9082467} - C:\WINDOWS\System32\msdxm.ocx
O4 - HKLM\..\Run: [Microsoft Works Update Detection] C:\Program Files\Common Files\Microsoft Shared\Works Shared\WkUFind.exe
O4 - HKLM\..\Run: [NvCplDaemon] RUNDLL32.EXE NvQTwk,NvCplDaemon initialize
O4 - HKLM\..\Run: [DellTouch] C:\WINDOWS\DELLMMKB.EXE
O4 - HKLM\..\Run: [MMTray] C:\Program Files\MusicMatch\MusicMatch Jukebox\mm_tray.exe
O4 - HKLM\..\Run: [KeyStone Version Control] C:\Program Files\KeyStone Learning\MeasureUp\cdtpUpdater.exe
O4 - HKLM\..\Run: [CMESys] "C:\Program Files\Common Files\CMEII\CMESys.exe"
O4 - HKLM\..\Run: [PromulGate] "C:\Program Files\DelFin\PromulGate\PgMonitr.exe"
O4 - HKLM\..\Run: [MediaLoads Installer] "C:\Program Files\DownloadWare\dw.exe" /H
O4 - HKLM\..\Run: [DownloadWare] "C:\Program Files\DownloadWare\dw.exe" /H
O4 - HKLM\..\Run: [DeltTray] DeltTray.exe
O4 - HKLM\..\Run: [AdaptecDirectCD] C:\Program Files\Adaptec\Easy CD Creator 5\DirectCD\DirectCD.exe
O4 - HKLM\..\Run: [AttuneClientEngine] C:\PROGRA~1\Aveo\Attune\bin\attune_ce.exe
O4 - HKLM\..\Run: [vptray] C:\PROGRA~1\SYMANT~1\SYMANT~1\vptray.exe
O4 - HKLM\..\Run: [NeroCheck] C:\WINDOWS\system32\NeroCheck.exe
O4 - HKLM\..\Run: [TkBellExe] C:\Program Files\Common Files\Real\Update_OB\evntsvc.exe -osboot
O4 - HKLM\..\Run: [Desksite CMA] C:\Program Files\desksite\bin\cma.exe
O4 - HKLM\..\RunOnce: [Q828026] "C:\WINDOWS\INF\unregmp2.exe" /UpdateWMP
O4 - HKCU\..\Run: [MSMSGS] "C:\Program Files\Messenger\msmsgs.exe" /background
O4 - HKCU\..\Run: [MoneyAgent] "C:\Program Files\Microsoft Money\System\Money Express.exe"
O4 - Global Startup: Adobe Gamma Loader.lnk = C:\Program Files\Common Files\Adobe\Calibration\Adobe Gamma Loader.exe
O4 - Global Startup: Date Manager.lnk = C:\Program Files\Date Manager\DateManager.exe
O4 - Global Startup: EtherGuard.lnk = C:\Program Files\SMC\EtherGuard\EtherGuard.exe
O4 - Global Startup: GStartup.lnk = C:\Program Files\Common Files\GMT\GMT.exe
O4 - Global Startup: Microsoft Works Calendar Reminders.lnk = ?
O9 - Extra button: Related - {c95fe080-8f5d-11d2-a20b-00aa003c157a} - C:\WINDOWS\web\related.htm
O9 - Extra 'Tools' menuitem: Show &Related Links - {c95fe080-8f5d-11d2-a20b-00aa003c157a} - C:\WINDOWS\web\related.htm
O9 - Extra button: Real.com - {CD67F990-D8E9-11d2-98FE-00C0F0318AFE} - C:\WINDOWS\System32\Shdocvw.dll
O9 - Extra button: Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\MSMSGS.EXE (file missing)
O9 - Extra 'Tools' menuitem: Windows Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\MSMSGS.EXE (file missing)
O12 - Plugin for .spop: C:\Program Files\Internet Explorer\Plugins\NPDocBox.dll
O16 - DPF: Microsoft WFC Forms Designer - file://D:\VJ98\wfcforms.cab
O16 - DPF: Visual Studio 6 Extensibility Libraries - file://D:\VJ98\vstudio6.cab
O16 - DPF: {1D2DCA0D-B30F-40AD-9690-087105F214EC} (IEDial Class) - http://usa-download.nocreditcard.com...eaccess2XP.cab
O16 - DPF: {56336BCB-3D8A-11D6-A00B-0050DA18DE71} (RdxIE Class) - http://207.188.7.150/143af02f9fef111...zip/RdxIE2.cab
O16 - DPF: {EF99BD32-C1FB-11D2-892F-0090271D4F88} (YBIOCtrl Class) - http://us.dl1.yimg.com/download.yaho...yiebio4029.cab

You got alot of nasties in your log. The first thing to do is download and install these 3 programs. After you install them update each one. Go ahead and remove everything they find. Your Kazza program will stop working but you should uninstall it and get the Kazza-Lite version which doesn't have all the spyware in it. Then post a new HJT log and see what nasties are left.
CWShredder
http://www.majorgeeks.com/download4086.html
Spybot Search & Destroy
http://www.safer-networking.org/
AdAware get all the plugins for Adaware
http://www.lavasoft.de/

I've seen worse logs

CWShredder isn't really necessary in this case. Kazaa Lite Ressurection is available for download here.