is there a simple solution for removing this message?

I think your best bet is to go to the spyware part of the forum and follow instructions there ...as I think it may be spyware related

Is this appearing at startup?

Did it just start happening?

Go to:

Start> Run

Type: Msconfig

On the Startup tab uncheck the entry for 'cfgmgr51'

Click OK and exit Msconfig.

Then restart your PC.

The error message is caused by the fact that the file isn't there (it's an 'orphan' startup entry) but Windows doesn't know that and keeps looking for it The process above should clear the file and you should not get the message again.

Also run this scan as it was possibly triggered by malware:

http://www.microsoft.com/security/ma...e/default.mspx