I need help . My computer start normally but mouse and keyboard sometimes not seemed to response . anyone know how and why this happen please help me solve it...

What type of connection is it? USB? Wireless? PS/2?

Have you checked the connections? Plug/ Unplug?

Any error messages?

Check Event viewer for system errors via

START > RUN > eventvwr.msc

nope no error message-
I'm using WINDOWS XP

And it use PS/2

have you checked the connections? Plug/ Un plug?

is this a new problem? did your mouse & keyboard work ok before?

When you say "sometimes not seem to respond" are you sure its the mouse & keyboard rather than the computer freezing?

Well I tried it already , unplug and re-plug , I even change my mouse and keyboard too... the computer did not freeze it works I means I can use the turn off button (push it and release) and the WINDOWS shut down - not turn it off forcefully.

Can you boot into safe mode?

A description of the Safe Mode Boot options in Windows XP

if yes then I would first try to boot into Last Good Configuration
or else try a System Restore to a point prior to this problem.

With the new mouse and keyboard it worked ok?....
Daft question time...sorry..
Are they plugged in the correct sockets ??
Do the mouse and keyboard work ok on another pc??

my mice and keyboards work properly on every other PC but still they sometimes not work on my PC...
My PC can start on safe mode but still keyboard sometimes not response on MS-DOS screen....

did you try a restore?

also check the Device Manager

Start > Run > devmgmt.msc

under Keyboards as well as Mice etc.

check for any errors or warnings... try to update drivers...

double click listing then try drivers & or troubleshooting