I have picked up a hijack browser called twikibar, it is my default browser and i can't change it or remove. Spyware; F-Secure, Windows Defender,and Webroot Spysweeper could not pick it.

That infection should show up in a HijackThis LOG and can likely be removed manually. Panda ActiveScan (free version) also seems to detect but not necessarily clean it:

http://www.google.ca/search?hl=en&q=...G=Search&meta=


There appear to be very few reported instances (7) with those reported found mostly in foreign language posts:

http://www.google.ca/search?hl=en&q=...G=Search&meta=


Do the following 'READ FIRST Procedures' found here if you require further assistance with this:

http://www.d-a-l.com/help/showthread.php?t=32403