O4 - HKLM\..\Run: [High Definition Audio Property Page Shortcut] HDAShCut.exe

What should I do with this one?

Castlecops start up gives me this information.

This is NOT a list of tasks/processes taken from Task Manager or the Close Program window (CTRL+ALT+DEL) but a list of startup applications, although you will find some of them listed via this method. Pressing CTRL+ALT+DEL identifies programs that are currently running - not necessarily at startup. For a list of tasks/processes you should try WinTasks 5 Standard/Professional from LIUtilities or the list at AnswersThatWork. Therefore, before ending a task/process via CTRL+ALT+DEL just because it has an "X" recommendation, please check whether it's in MSCONFIG or the registry first. An example would be "svchost.exe" - which doesn't appear in either under normal conditions but does via CTRL+ALT+DEL. If in doubt, don't do anything.

I haven't tampered with the svchost.exe as it still shows as stated above using Task Manager. Should it be showing there as I also have spoolsv.exe in there as well.

Try typing them in here http://www.castlecops.com/StartupList.html.

What I'm thinking are that these are in SYSTEM32 should be in place but are prone to infection and I'm clean??

Cheers again for looking.