Spybot and TrojanHunter show Hotkeyhook as possible threats.

Spybot shows H@tkeyH@@k as possible threat

and TrojanHunter shows Rise of Nations/imsdox-ron.exe/an13sx7.exe (KLog.HotkeyHook) or KLog.HotkeyHook.100)

the file in question from TrojanHunter is a trainer for the game rise of nations should I be concerned?

Spybot and TrojanHunter show Hotkeyhook as possible threats.

Could be an issue. Look in the 'advanced' TAB in this link:

http://www.sophos.com/security/analyses/trojtibikb.html

Troj/Tibik-B may copy itself to <Windows system folder>\msview with the following filenames:

Rise of Nations - Thrones & Patriots Microsoft crack.exe

Alternately,
Here is another game where hotkeyhook is deemed to be trojan because of its suspect detected keylogging behavior (use Edit>Find>keylogger <-- keyword):

http://www.hongfire.com/forum/showth...t=30489&page=9

This trainer uses Hotkeyhook in order to detect the key pressed IN THE GAME . Most AV will detect it as a trojan . keylogger.

If you are still doubtful, you could consider uninstalling and reinstalling the game to verify that the Hotkeyhook feature is indeed part of the game. Or send an email to the game's maker advising and requesting clarification on the threat alert being generated.