PC runs slow, sometimes won't shut down via commands. Also getting a "REGISTRY CHANGE DENIED" (MSMSGS) after responding to a spybot prompt. Could someone review this log please.

Logfile of HijackThis v1.99.1
Scan saved at 8:00:36 PM, on 8/23/2005
Platform: Windows XP SP2 (WinNT 5.01.2600)
MSIE: Internet Explorer v6.00 SP2 (6.00.2900.2180)

Running processes:
C:\WINDOWS\System32\smss.exe
C:\WINDOWS\system32\winlogon.exe
C:\WINDOWS\system32\services.exe
C:\WINDOWS\system32\lsass.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\System32\svchost.exe
C:\WINDOWS\system32\brsvc01a.exe
C:\WINDOWS\system32\spoolsv.exe
C:\WINDOWS\system32\brss01a.exe
C:\Program Files\Common Files\Symantec Shared\ccEvtMgr.exe
C:\WINDOWS\system32\cisvc.exe
C:\Program Files\Executive Software\Diskeeper\DkService.exe
C:\Program Files\Common Files\EPSON\EBAPI\SAgent2.exe
C:\Program Files\Norton SystemWorks\Norton AntiVirus\navapsvc.exe
C:\Program Files\Norton SystemWorks\Norton Utilities\NPROTECT.EXE
C:\WINDOWS\System32\nvsvc32.exe
C:\PROGRA~1\NORTON~1\SPEEDD~1\nopdb.exe
C:\Program Files\Common Files\Symantec Shared\Security Center\SymWSC.exe
C:\WINDOWS\Explorer.EXE
C:\WINDOWS\System32\DSentry.exe
C:\Program Files\Common Files\Real\Update_OB\realsched.exe
C:\Program Files\Roxio\Easy CD Creator 5\DirectCD\DirectCD.exe
C:\WINDOWS\system32\NWTRAY.EXE
C:\PROGRA~1\BILLPS~1\WINPAT~1\WinPatrol.exe
C:\Program Files\Common Files\Symantec Shared\ccApp.exe
C:\Program Files\Viewpoint\Viewpoint Manager\ViewMgr.exe
C:\Program Files\iTunes\iTunesHelper.exe
C:\PROGRA~1\PANICW~1\POP-UP~1\PSFree.exe
C:\WINDOWS\system32\RUNDLL32.EXE
C:\Program Files\Dell Support\DSAgnt.exe
C:\Program Files\iPod\bin\iPodService.exe
C:\Program Files\Spybot - Search & Destroy\TeaTimer.exe
C:\Program Files\Digital Line Detect\DLG.exe
C:\WINDOWS\system32\ntvdm.exe
C:\Program Files\Internet Explorer\iexplore.exe
C:\WINDOWS\system32\cidaemon.exe
C:\Program Files\Messenger\msmsgs.exe
C:\Program Files\HiJack This\HijackThis.exe

R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Default_Page_URL = http://www.dellnet.com/
R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Start Page = http://wso.williams.edu/
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = http://www.dellnet.com/
R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Start Page_bak = http://wso.williams.edu/
R1 - HKCU\Software\Microsoft\Windows\CurrentVersion\Int ernet Settings,ProxyOverride = http://localhost;
O2 - BHO: (no name) - {53707962-6F74-2D53-2644-206D7942484F} - C:\Program Files\Spybot - Search & Destroy\SDHelper.dll
O2 - BHO: Google Toolbar Helper - {AA58ED58-01DD-4d91-8333-CF10577473F7} - c:\program files\google\googletoolbar1.dll
O2 - BHO: NAV Helper - {BDF3E430-B101-42AD-A544-FADC6B084872} - C:\Program Files\Norton SystemWorks\Norton AntiVirus\NavShExt.dll
O3 - Toolbar: Norton AntiVirus - {42CDD1BF-3FFB-4238-8AD1-7859DF00B1D6} - C:\Program Files\Norton SystemWorks\Norton AntiVirus\NavShExt.dll
O3 - Toolbar: &Google - {2318C2B1-4965-11d4-9B18-009027A5CD4F} - c:\program files\google\googletoolbar1.dll
O4 - HKLM\..\Run: [NvCplDaemon] RUNDLL32.EXE C:\WINDOWS\System32\NvCpl.dll,NvStartup
O4 - HKLM\..\Run: [DVDSentry] C:\WINDOWS\System32\DSentry.exe
O4 - HKLM\..\Run: [TkBellExe] "C:\Program Files\Common Files\Real\Update_OB\realsched.exe" -osboot
O4 - HKLM\..\Run: [AdaptecDirectCD] "C:\Program Files\Roxio\Easy CD Creator 5\DirectCD\DirectCD.exe"
O4 - HKLM\..\Run: [nwiz] nwiz.exe /install
O4 - HKLM\..\Run: [NWTRAY] NWTRAY.EXE
O4 - HKLM\..\Run: [WinPatrol] "C:\PROGRA~1\BILLPS~1\WINPAT~1\WinPatrol.exe"
O4 - HKLM\..\Run: [ccApp] "C:\Program Files\Common Files\Symantec Shared\ccApp.exe"
O4 - HKLM\..\Run: [ccRegVfy] "C:\Program Files\Common Files\Symantec Shared\ccRegVfy.exe"
O4 - HKLM\..\Run: [ViewMgr] C:\Program Files\Viewpoint\Viewpoint Manager\ViewMgr.exe
O4 - HKLM\..\Run: [iTunesHelper] C:\Program Files\iTunes\iTunesHelper.exe
O4 - HKLM\..\Run: [Symantec NetDriver Monitor] C:\PROGRA~1\SYMNET~1\SNDMon.exe /Consumer
O4 - HKCU\..\Run: [PopUpStopperFreeEdition] "C:\PROGRA~1\PANICW~1\POP-UP~1\PSFree.exe"
O4 - HKCU\..\Run: [NvMediaCenter] RUNDLL32.EXE C:\WINDOWS\System32\NVMCTRAY.DLL,NvTaskbarInit
O4 - HKCU\..\Run: [DellSupport] "C:\Program Files\Dell Support\DSAgnt.exe" /startup
O4 - HKCU\..\Run: [SpybotSD TeaTimer] C:\Program Files\Spybot - Search & Destroy\TeaTimer.exe
O4 - Global Startup: Digital Line Detect.lnk = ?
O4 - Global Startup: KeyAccess.lnk = ?
O4 - Global Startup: Microsoft Office.lnk = C:\Program Files\Microsoft Office\Office10\OSA.EXE
O8 - Extra context menu item: &AIM Search - res://C:\Program Files\AIM Toolbar\AIMBar.dll/aimsearch.htm
O8 - Extra context menu item: &Google Search - res://C:\Program Files\Google\GoogleToolbar1.dll/cmsearch.html
O8 - Extra context menu item: &Translate English Word - res://C:\Program Files\Google\GoogleToolbar1.dll/cmwordtrans.html
O8 - Extra context menu item: Backward Links - res://C:\Program Files\Google\GoogleToolbar1.dll/cmbacklinks.html
O8 - Extra context menu item: Cached Snapshot of Page - res://C:\Program Files\Google\GoogleToolbar1.dll/cmcache.html
O8 - Extra context menu item: E&xport to Microsoft Excel - res://C:\PROGRA~1\MICROS~2\Office10\EXCEL.EXE/3000
O8 - Extra context menu item: Similar Pages - res://C:\Program Files\Google\GoogleToolbar1.dll/cmsimilar.html
O8 - Extra context menu item: Translate Page into English - res://C:\Program Files\Google\GoogleToolbar1.dll/cmtrans.html
O9 - Extra button: AIM - {AC9E2541-2814-11d5-BC6D-00B0D0A1DE45} - C:\PROGRA~1\AIM\aim.exe
O9 - Extra button: Real.com - {CD67F990-D8E9-11d2-98FE-00C0F0318AFE} - C:\WINDOWS\System32\Shdocvw.dll
O9 - Extra button: Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\msmsgs.exe
O9 - Extra 'Tools' menuitem: Windows Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\msmsgs.exe
O16 - DPF: {17492023-C23A-453E-A040-C7C580BBF700} (Windows Genuine Advantage Validation Tool) - http://go.microsoft.com/fwlink/?linkid=39204
O16 - DPF: {7B297BFD-85E4-4092-B2AF-16A91B2EA103} (WScanCtl Class) - http://www3.ca.com/securityadvisor/v...fo/webscan.cab
O16 - DPF: {9FC5238F-12C4-454F-B1B5-74599A21DE47} (Webshots Photo Uploader) - http://community.webshots.com/html/WSPhotoUploader.CAB
O17 - HKLM\System\CCS\Services\Tcpip\..\{0A12318A-69EF-4BEF-B691-9792167D0954}: Domain = williams.edu
O17 - HKLM\System\CS1\Services\Tcpip\..\{0A12318A-69EF-4BEF-B691-9792167D0954}: Domain = williams.edu
O17 - HKLM\System\CS2\Services\Tcpip\..\{0A12318A-69EF-4BEF-B691-9792167D0954}: Domain = williams.edu
O20 - AppInit_DLLs: KATRACK.DLL
O23 - Service: BrSplService (Brother XP spl Service) - brother Industries Ltd - C:\WINDOWS\system32\brsvc01a.exe
O23 - Service: Symantec Event Manager (ccEvtMgr) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\ccEvtMgr.exe
O23 - Service: Symantec Password Validation Service (ccPwdSvc) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\ccPwdSvc.exe
O23 - Service: Client Update Service for Novell (cusrvc) - Novell, Inc. - C:\WINDOWS\System32\cusrvc.exe
O23 - Service: Diskeeper - Executive Software International, Inc. - C:\Program Files\Executive Software\Diskeeper\DkService.exe
O23 - Service: EPSON Printer Status Agent2 (EPSONStatusAgent2) - SEIKO EPSON CORPORATION - C:\Program Files\Common Files\EPSON\EBAPI\SAgent2.exe
O23 - Service: iPod Service (iPodService) - Apple Computer, Inc. - C:\Program Files\iPod\bin\iPodService.exe
O23 - Service: Norton AntiVirus Auto Protect Service (navapsvc) - Symantec Corporation - C:\Program Files\Norton SystemWorks\Norton AntiVirus\navapsvc.exe
O23 - Service: Intel NCS NetService (NetSvc) - Intel(R) Corporation - C:\Program Files\Intel\NCS\Sync\NetSvc.exe
O23 - Service: Norton Unerase Protection (NProtectService) - Symantec Corporation - C:\Program Files\Norton SystemWorks\Norton Utilities\NPROTECT.EXE
O23 - Service: NVIDIA Driver Helper Service (NVSvc) - NVIDIA Corporation - C:\WINDOWS\System32\nvsvc32.exe
O23 - Service: ScriptBlocking Service (SBService) - Symantec Corporation - C:\PROGRA~1\COMMON~1\SYMANT~1\SCRIPT~1\SBServ.exe
O23 - Service: Symantec Network Drivers Service (SNDSrvc) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\SNDSrvc.exe
O23 - Service: Speed Disk service - Symantec Corporation - C:\PROGRA~1\NORTON~1\SPEEDD~1\nopdb.exe
O23 - Service: SymWMI Service (SymWSC) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\Security Center\SymWSC.exe

Is anyone going to reply to this question / problem?