I took a look at my log today i i wasn't sure if it was clean.
In my memory some new things have appeared in my log(im not sure)
Logfile of HijackThis v1.99.1
Scan saved at 18:00:19, on 03/04/2005
Platform: Windows XP (WinNT 5.01.2600)
MSIE: Internet Explorer v6.00 (6.00.2600.0000)

Running processes:
C:\WINDOWS\System32\smss.exe
C:\WINDOWS\system32\winlogon.exe
C:\WINDOWS\system32\services.exe
C:\WINDOWS\system32\lsass.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\System32\svchost.exe
C:\WINDOWS\system32\LEXBCES.EXE
C:\WINDOWS\system32\spoolsv.exe
C:\WINDOWS\system32\LEXPPS.EXE
C:\WINDOWS\Explorer.EXE
C:\PROGRA~1\COMMON~1\AOL\ACS\AOLacsd.exe
C:\Program Files\Alwil Software\Avast4\aswUpdSv.exe
C:\Program Files\Alwil Software\Avast4\ashServ.exe
C:\PROGRA~1\McAfee.com\PERSON~1\MPFSERVICE.exe
C:\WINDOWS\System32\svchost.exe
C:\windows\system\hpsysdrv.exe
C:\WINDOWS\System32\igfxtray.exe
C:\WINDOWS\System32\hkcmd.exe
C:\HP\KBD\KBD.EXE
C:\WINDOWS\system32\dla\tfswctrl.exe
C:\WINDOWS\System32\gsicon.exe
C:\WINDOWS\System32\dslagent.exe
C:\PROGRA~1\McAfee.com\PERSON~1\MpfTray.exe
C:\PROGRA~1\ALWILS~1\Avast4\ashDisp.exe
C:\Program Files\Lexmark X5100 Series\lxbabmgr.exe
C:\Program Files\Common Files\AOL\ACS\AOLDial.exe
C:\Program Files\Lexmark X5100 Series\lxbabmon.exe
C:\Program Files\Microsoft AntiSpyware\gcasServ.exe
C:\Program Files\AOL 9.0\aoltray.exe
C:\Program Files\hp center\137903\Program\BackWeb-137903.exe
C:\PROGRA~1\McAfee.com\PERSON~1\Mp***ent.exe
C:\Program Files\Microsoft AntiSpyware\gcasDtServ.exe
C:\Program Files\Alwil Software\Avast4\ashMaiSv.exe
C:\Program Files\Alwil Software\Avast4\ashWebSv.exe
C:\WINDOWS\System32\wuauclt.exe
C:\Program Files\Internet Explorer\IEXPLORE.EXE
C:\Program Files\Skype\Phone\Skype.exe
C:\Program Files\MSN Messenger\msnmsgr.exe
C:\Program Files\Internet Explorer\IEXPLORE.EXE
C:\Documents and Settings\Owner\Desktop\Spyware AND virus\hijackthis.exe

R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Start Page = http://www.google.co.uk/
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = http://www.msn.co.uk
R1 - HKCU\Software\Microsoft\Internet Explorer\Search,Default_Search_URL = about:blank
O2 - BHO: AcroIEHlprObj Class - {06849E9F-C8D7-4D59-B87D-784B7D6BE0B3} - C:\Program Files\Adobe\Acrobat 5.0\Reader\ActiveX\AcroIEHelper.ocx
O2 - BHO: (no name) - {53707962-6F74-2D53-2644-206D7942484F} - C:\PROGRA~1\SPYBOT~1\SDHelper.dll
O4 - HKLM\..\Run: [hpsysdrv] c:\windows\system\hpsysdrv.exe
O4 - HKLM\..\Run: [IgfxTray] C:\WINDOWS\System32\igfxtray.exe
O4 - HKLM\..\Run: [HotKeysCmds] C:\WINDOWS\System32\hkcmd.exe
O4 - HKLM\..\Run: [KBD] C:\HP\KBD\KBD.EXE
O4 - HKLM\..\Run: [StorageGuard] "C:\Program Files\VERITAS Software\Update Manager\sgtray.exe" /r
O4 - HKLM\..\Run: [dla] C:\WINDOWS\system32\dla\tfswctrl.exe
O4 - HKLM\..\Run: [Recguard] C:\WINDOWS\SMINST\RECGUARD.EXE
O4 - HKLM\..\Run: [NvCplDaemon] RUNDLL32.EXE NvQTwk,NvCplDaemon initialize
O4 - HKLM\..\Run: [nwiz] nwiz.exe /install
O4 - HKLM\..\Run: [GSICONEXE] gsicon.exe
O4 - HKLM\..\Run: [DSLAGENTEXE] dslagent.exe USB
O4 - HKLM\..\Run: [MPFExe] C:\PROGRA~1\McAfee.com\PERSON~1\MpfTray.exe
O4 - HKLM\..\Run: [avast!] C:\PROGRA~1\ALWILS~1\Avast4\ashDisp.exe
O4 - HKLM\..\Run: [Lexmark X5100 Series] "C:\Program Files\Lexmark X5100 Series\lxbabmgr.exe"
O4 - HKLM\..\Run: [AOLDialer] C:\Program Files\Common Files\AOL\ACS\AOLDial.exe
O4 - HKLM\..\Run: [gcasServ] "C:\Program Files\Microsoft AntiSpyware\gcasServ.exe"
O4 - HKCU\..\Run: [Microsoft Works Update Detection] c:\Program Files\Microsoft Works\WkDetect.exe
O4 - Global Startup: AOL 9.0 Tray Icon.lnk = C:\Program Files\AOL 9.0\aoltray.exe
O4 - Global Startup: hp center.lnk = C:\Program Files\hp center\137903\Program\BackWeb-137903.exe
O4 - Global Startup: Utility.lnk = ?
O9 - Extra button: Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\MSMSGS.EXE
O9 - Extra 'Tools' menuitem: Windows Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\MSMSGS.EXE
O12 - Plugin for .spop: C:\Program Files\Internet Explorer\Plugins\NPDocBox.dll
O16 - DPF: {4A3CF76B-EC7A-405D-A67D-8DC6B52AB35B} (QDiagAOLCCUpdateObj Class) - http://aolcc.aolsvc.aol.co.uk/comput...up/qdiagcc.cab
O16 - DPF: {6414512B-B978-451D-A0D8-FCFDF33E833C} (WUWebControl Class) - http://v5.windowsupdate.microsoft.co...?1110044883665
O16 - DPF: {B38870E4-7ECB-40DA-8C6A-595F0A5519FF} (MsnMessengerSetupDownloadControl Class) - http://messenger.msn.com/download/Ms...Downloader.cab
O17 - HKLM\System\CCS\Services\Tcpip\..\{47669FFD-751A-4E47-A58B-C7D548A68AE0}: NameServer = 69.50.188.180,195.225.176.37
O17 - HKLM\System\CCS\Services\Tcpip\..\{6B96C6B7-A9CC-42F0-B34C-553A065063E5}: NameServer = 69.50.188.180 195.225.176.37
O17 - HKLM\System\CCS\Services\Tcpip\..\{91898611-0032-4FE1-90FA-714417E4C957}: NameServer = 69.50.188.180,195.225.176.37
O17 - HKLM\System\CCS\Services\Tcpip\..\{FC1727A3-6C3E-4B6D-85B3-46B4DC4EFF7D}: NameServer = 69.50.188.180,195.225.176.37
O17 - HKLM\System\CS1\Services\Tcpip\..\{47669FFD-751A-4E47-A58B-C7D548A68AE0}: NameServer = 69.50.188.180,195.225.176.37
O17 - HKLM\System\CS2\Services\Tcpip\..\{47669FFD-751A-4E47-A58B-C7D548A68AE0}: NameServer = 69.50.188.180,195.225.176.37
O20 - Winlogon Notify: igfxcui - C:\WINDOWS\SYSTEM32\igfxsrvc.dll
O23 - Service: AOL Connectivity Service (AOL ACS) - America Online, Inc. - C:\PROGRA~1\COMMON~1\AOL\ACS\AOLacsd.exe
O23 - Service: avast! iAVS4 Control Service (aswUpdSv) - Unknown owner - C:\Program Files\Alwil Software\Avast4\aswUpdSv.exe
O23 - Service: avast! Antivirus - Unknown owner - C:\Program Files\Alwil Software\Avast4\ashServ.exe
O23 - Service: avast! Mail Scanner - Unknown owner - C:\Program Files\Alwil Software\Avast4\ashMaiSv.exe" /service (file missing)
O23 - Service: avast! Web Scanner - Unknown owner - C:\Program Files\Alwil Software\Avast4\ashWebSv.exe" /service (file missing)
O23 - Service: LexBce Server (LexBceS) - Lexmark International, Inc. - C:\WINDOWS\system32\LEXBCES.EXE
O23 - Service: McAfee Personal Firewall Service (MpfService) - McAfee Corporation - C:\PROGRA~1\McAfee.com\PERSON~1\MPFSERVICE.exe
O23 - Service: NVIDIA Driver Helper Service (NVSvc) - NVIDIA Corporation - C:\WINDOWS\System32\nvsvc32.exe

I am unsure on these entries:
O12 - Plugin for .spop: C:\Program Files\Internet Explorer\Plugins\NPDocBox.dll
O4 - HKLM\..\Run: [NvCplDaemon] RUNDLL32.EXE NvQTwk,NvCplDaemon initialize
O4 - HKLM\..\Run: [nwiz] nwiz.exe /install
O4 - HKLM\..\Run: [hpsysdrv] c:\windows\system\hpsysdrv.exe
O4 - HKLM\..\Run: [IgfxTray] C:\WINDOWS\System32\igfxtray.exe
O4 - HKLM\..\Run: [HotKeysCmds] C:\WINDOWS\System32\hkcmd.exe
i would realy be alot happyer if you explaned these entries to me.

O12 - Plugin for .spop: C:\Program Files\Internet Explorer\Plugins\NPDocBox.dll- Not sure whats it for buts it legitimate

O4 - HKLM\..\Run: [NvCplDaemon] RUNDLL32.EXE NvQTwk,NvCplDaemon initialize
O4 - HKLM\..\Run: [nwiz] nwiz.exe /install- Related to Nvidia Graphics cards.

O4 - HKLM\..\Run: [hpsysdrv] c:\windows\system\hpsysdrv.exe- This item keeps track of how many times the system has been recovered and the times of the first and last recoveries done on the system. Leaving unchecked will sometimes prevent the Keyboard Manager program from detecting that the computer is an HP. Since this program/driver was only made to run on HP, if it can't tell that it is an HP it will not run. If unchecked, it can prevent the running of the Application Recovery CDs, the use of the multimedia keys, and the HP Instant Support. Also seen that without it running, the Riptide Sound card that was installed on some older HP computers stops working

O4 - HKLM\..\Run: [IgfxTray] C:\WINDOWS\System32\igfxtray.exe- Quick access to the control panel via a System Tray icon for graphics based upon the Intel chipsets (ie, i810). These chipsets are often included on motherboards. Available via Start -> Settings -> Control Panel

O4 - HKLM\..\Run: [HotKeysCmds] C:\WINDOWS\System32\hkcmd.exe- Installed by the Intel 810 and 815 chipset graphic drivers. If you want the Ctrl Alt F12 or similar keypresses to access Intel's customised graphics properties, you need it, otherwise not. Can be disabled via the Display Properties in Control Panel.

So owen any thing i should get rid of?

I'd leave them really, nothing like a major resource hog there.