I wanted to build a computer with multiple 400gb hard drives in it (don't ask). They are SATA hard drives. I contacted the motherboard company and they said the board I picked could handle it. Are there any other factors involved?

Here is a link to a description & tests of 2x400gb Seagate drives:

http://www.cluboverclocker.com/revie...00.8/index.htm

Hope this helps.