Running Win 2000 sp4 and lates IE. Sudenly when I try to start IE it flashes and closes. I use McAfee Virus Center, Ad-Aware and Spybot. Any ideas?

See if this helps:

http://windowsxp.mvps.org/IEFAQ.htm#IEOpen

If no luck there then:

Please follow owen's Instructions and then post your log in a new thread in the Spyware, Adware, Viruses and HijackThis Logs section. (Not in this section please).